antiepileptic medications

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Saturday, September 2 2006.

 
        A) Gabapentin is metabolized primarily by the kidney.
 
        B) Felbamate is indicated for treatment of Lennox-Gastaut syndrome.
 
        C) Oxcarbazepine is indicated for treatement of complex partial seizures.
 
        D) Tiagabine is the drug of first choice for patients with absence seizures only.
 
        E) Clonazepam causes increase of GABA-mediated currents.
 

 

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This question was created on September 02, 2006 by .
This question was last modified on September 02, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Gabapentin is metabolized primarily by the kidney.

This answer is incorrect.

The statement, "Gabapentin is metabolized primarily by the kidney." is true.
Gabapentin causes increase of GABA-mediated currents, is a glutamate receptor antagonist, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is metabolized primarily by the kidney, is approved as adjunct therapy only, is excreted in breast milk, and has no known significant interactions with other AEDs.  (See References)

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B) Felbamate is indicated for treatment of Lennox-Gastaut syndrome.

This answer is incorrect.

The statement, "Felbamate is indicated for treatment of Lennox-Gastaut syndrome." is true.
Felbamate is indicated for treatment of Lennox-Gastaut syndrome.  (See References)

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C) Oxcarbazepine is indicated for treatement of complex partial seizures.

This answer is incorrect.

The statement, "Oxcarbazepine is indicated for treatement of complex partial seizures." is true.
Oxcarbazepine causes reduction of sodium currents, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for treatment of partial seizures with secondary generalization, is metabolized primarily in the liver, is approved as adjunct therapy only, induces hepatic enzymes, and is excreted in breast milk.  (See References)

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D) Tiagabine is the drug of first choice for patients with absence seizures only.

This answer is correct.

The statement, "Tiagabine is the drug of first choice for patients with absence seizures only." is false.
Tiagabine causes reduction of sodium currents, is indicated for treatment of partial seizures, is metabolized primarily in the liver, and is approved as adjunct therapy only.  (See References)

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E) Clonazepam causes increase of GABA-mediated currents.

This answer is incorrect.

The statement, "Clonazepam causes increase of GABA-mediated currents." is true.
Clonazepam causes reduction of sodium currents, causes increase of GABA-mediated currents, is indicated for treatment of absence seizures, is indicated for treatment of atypical absence seizures, is indicated for treatment of atonic seizures, is indicated for treatment of myoclonic seizures, is metabolized primarily in the liver, and is a known teratogen, or evidence for its teratogenicity exists.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.

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pathology
antiepileptic medications
Question ID: 540025025
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/02/2006
Estimated Permutations: 0